报告题目:
RECQL4促进DNA双链断裂损伤修复阻止疾病发生
Title:
RECQL4 promotes repair of DNA double-strand break to prevent diseases
SPEAKER:
HUIMING LU
EDUCATION:
2009.6 Ph.D., Zhejiang University, China
Major: Biophysics
Mentors: Prof. Yuejin Hua and Prof. Binghui Shen
2004.6 B. S., Zhejiang University, China
Major: Agronomy
Mentor: Prof. Yuejin Hua
时间:
2017年3月8日
地点:
浙江大学华家池校区中心南楼106室
RESEARCH STATEMENT
DNA double-strand breaks (DSBs) induce genome instability, trigger cellular senescence and cell death, and further lead to tissue dysfunction, aging and tumours. Detailed mechanisms of DSB repair and pathway choice as well as related DNA damage response (DDR) are still largely unclear. I am greatly interested in pursuing the molecular mechanisms of DDR and repair of DSB, biological consequences of DSB repair deficiency in cell fate, as well as its correlation with premature aging and tumorigenesis. In addition, I would like to explore intervention approaches to DNA repair deficiency-induced diseases for potential application in clinics.
PUBLICATIONS:
1. Lu H*, Shamanna RA*, Keijzers G, Anand R, Rasmussen LJ, Cejka P, Croteau DL Bohr VA.
RECQL4 promotes DNA end resection in repair of DNA double strand breaks. Cell Rep, 2016, 16:1-13. (*, Equal contributions)
2. Shamanna RA, Lu H, de Freitas J, Tian J, Croteau DL and Bohr VA. WRN regulates pathway choice between classical and alternative non-homologous end joining as it maintains genome stability. Nat Commun, 2016; 7: 13785.
3. Shamanna RA, Lu H, Croteau DL, Arora A, Agarwal D, Ball G, Aleskandarany M, Ellis I, Pommier Y, Madhusudan S, Bohr VA. Camptothecin targets WRN protein: mechanism and relevance in clinical breast cancer. Oncotarget, 2016, 7(12):13269-84.