关于美国国立老年医学研究中心陆辉明助理研究员学术报告的通知

编辑:admin 时间:2017年03月07日 访问次数:402

报告题目:
RECQL4促进DNA双链断裂损伤修复阻止疾病发生
Title
RECQL4 promotes repair of DNA double-strand break to prevent diseases
SPEAKER:
HUIMING LU
EDUCATION:  
2009.6  Ph.D., Zhejiang University, China
Major: Biophysics
Mentors: Prof. Yuejin Hua and Prof. Binghui Shen
2004.6  B. S., Zhejiang University, China
Major: Agronomy 
Mentor: Prof. Yuejin Hua 
时间:
2017年3月8日
地点:
浙江大学华家池校区中心南楼106
RESEARCH STATEMENT
DNA  double-strand  breaks  (DSBs)  induce  genome  instability,  trigger  cellular  senescence  and  cell death, and further lead to tissue dysfunction, aging and tumours. Detailed mechanisms of DSB repair and pathway choice as well as related DNA damage response (DDR) are still largely unclear.  I am greatly  interested  in  pursuing  the  molecular  mechanisms  of  DDR  and  repair  of  DSB,  biological consequences of DSB  repair deficiency  in cell  fate, as well as  its correlation with premature aging and  tumorigenesis.  In  addition,  I  would  like  to  explore  intervention  approaches  to  DNA  repair deficiency-induced diseases for potential application in clinics.
PUBLICATIONS:
1.  Lu H*, Shamanna RA*, Keijzers G, Anand R, Rasmussen LJ, Cejka P, Croteau DL Bohr VA.
RECQL4 promotes DNA end  resection  in  repair of DNA double  strand breaks. Cell Rep, 2016, 16:1-13. (*, Equal contributions)
2.  Shamanna RA, Lu H, de Freitas  J, Tian  J, Croteau DL  and Bohr VA. WRN  regulates pathway choice  between  classical  and  alternative  non-homologous  end  joining  as  it  maintains  genome stability. Nat Commun, 2016; 7: 13785.
3.  Shamanna  RA,  Lu  H,  Croteau  DL,  Arora  A,  Agarwal  D,  Ball  G,  Aleskandarany M,  Ellis  I, Pommier  Y,  Madhusudan  S,  Bohr  VA.  Camptothecin  targets WRN  protein:  mechanism  and relevance in clinical breast cancer. Oncotarget, 2016, 7(12):13269-84.