报告时间：8月17日（周六）上午9:00-11:00
报告地点：紫金港校区农生环大楼C912
报告人/题目:
(1) 荷兰皇家人文和科学院Pierre de Wit院士，New Effectors of the fungal tomato pathogen Cladosporium fulvum and its relatives; what have we learned so far?
(2) 美国康奈尔大学Jian Hua副教授，Cell cycle progression and plant disease resistance, a connection revealed by Arabidopsis autoimmune mutants
欢迎各位老师和研究生参加！
报告联系人：蔡新忠 （电话：88982936）
附：Pierre de Wit教授简介
1999年当选荷兰皇家人文和科学院院士(Member Royal Netherlands Academy of Arts and Sciences (KNAW))。
2007年至今担任荷兰皇家人文和科学院生物学部秘书长。
1999-2004年为荷兰Wageningen大学实验植物学研究生院院长。
2005-2007年为分子植物与微生物互作国际学会（IS-MPMI）主席。
2003-至今为荷兰生物系统基因组学中心负责人。
1992年至今一直为Wageningen大学植物病理学总负责人。
Pierre de Wit教授为资深植物病理学家，从事番茄与叶霉菌（Cladosporiun fulvum）互作机理研究30多年。他实验室在世界上最早克隆了真菌无毒基因(Cladosporiun fulvum无毒基因Avr9和Avr4)，在番茄与叶霉菌互作机理方面取得许多突破性成果，是植物病原真菌效应蛋白（effector）功能研究的先驱和杰出代表。在Nature，Science，Plant Cell, PNAS, Plant Journal, Annual Review of Phytopathology, Molecular Microbiology, Plant Physiology, Journal of Biological Chemistry, Molecular Plant-Microbe Interactions, Plant Molecular Biology等国际植物科学和植物病理学核心期刊发表论文150多篇，被引用共5580多次，H指数(h-factor)高达44, 为植物病理学发展，尤其是植物与病原物互作分子机理方面的理解，作出了杰出贡献。他多次担任植物病理学和MPMI国际大会主席，兼任国际上多所大学和研究机构的研究顾问。曾任Plant Journal，MPMI，Molecular Breeding，Current Genetics等多种国际植物科学和植物病理学核心期刊的编委, 现任FEMS Microbiology Reviews, Fungal Genetics and Biology等期刊编委以及Phytoparasitica期刊顾问。2003年被ISI选为高引用作者；2007年被美国植病学会授予Noel T. Keen分子植病杰出奖(Noel T. Keen award for excellence in molecular plant pathology (award from APS: American Phytopathological Society)).
部分论文：
Joosten, MHAJ, Cozijnsen, AJ and De Wit, PJGM (1994). Host resistance to a fungal tomato pathogen lost by a single base-pair change in an avirulence gene. Nature 367, 384-387.
Kooman-Gersmann, M, Honée, G, Bonnema, G, and De Wit, PJGM (1996). A high affinity binding site for the AVR9 peptide elicitor of Cladosporium fulvum is present on plasma membranes of tomato and other solanceous plants The Plant Cell 8, 929-938.
Laugé R, Joosten MHAJ, Haanstra J.P.W., Goodwin, P.H., Lindhout, P., and de Wit, P.J.G.M. (1998). Successful search for a resistance gene in tomato targeted against a virulence factor of a fungal pathogen Proceedings of the National Academy of Sciences USA 95, 14-9018.
Van der Hoorn, RAL, Kruijt, M, Roth, R, Brandwagt, BF, Joosten, MHAJ, de Wit, PJGM (2001). Intragenic recombination generated two distinct Cf genes that mediate AVR9 recognition in the natural population Lycopersicon pimpinellifolium. Proceedings of the National Academy of Sciences of the United States of America 98, 10493-10498.
Luderer, R, Takken, FLW, De Wit, PJGM, Joosten, MHAJ (2002). Cladosporium fulvum overcomes Cf-2-mediated resistance by producing truncated AVR2 elicitor proteins. Molecular Microbiology 45, 875-884.
Rooney, HCE., van ‘t Klooster, JW, van der Hoorn, RAL Joosten, MHAJ, Jones, JDG and de Wit, PJGM (2005).Cladosporium Avr2 inhibits tomato Rcr3 protease required for Cf-2-dependent disease resistance. Science, 308, 1783-1786, 2005.
van der Hoorn RAL, Wulff BBH, Rivas S, Durrant MC, van der Ploeg A, de Wit PJGM, Jones JDG (2005). Structure-function analysis of Cf-9, a receptor-like protein with extracytoplasmic leucine-rich repeats. The Plant Cell 17, 1000-1015.
Van den Burg, HA, Harrison, SJ, Joosten, MHAJ, Vervoort, J, and de Wit, PJGM (2006). Cladosporium fulvum Avr4 protects fungal cell walls against hydrolysis by plant chitinases accumulating during infection. Molecular Plant-Microbe Interactions. 12, 1420-1430.
Stergiopoulos I, De Kock MJD, Lindhout P, de Wit PJGM (2007). Allelic variation in the effector genes of the tomato pathogen Cladosporium fulvum reveals different modes of adaptive evolution. Molecularr Plant-Microbe Interacions. 20, 1271-83.
Van Esse HP, van ‘t Klooster JW, Bolton MD, Yadeta K, van Baarlen P, Boeren S, Vervoort J, de Wit PJGM and ThommaBPHJ (2008). The Cladosporium fulvum virulence protein Avr2 inhibits host proteases required for basal defense. The Plant Cell 20, 1948–1963.
Stergiopoulos, I and de Wit, PJGM (2009) Fungal effectors. Annual Review of Phytopathology, 47, 245-258.
Stergiopoulos I, van den Burg HA, Okmen B, Beenen HG, van Liere S, Kema GHJ, de Wit, PJGM(2010). Tomato Cf resistance proteins mediate recognition of cognate homologous effectors from fungi pathogenic on dicots and monocots. Proceedings of the National Academy of Sciences of the United States of America 107(16): 7610-7615.
Jian Hua副教授简介：
华健副教授1989年获复旦大学生物学学士学位，1992年获上海植生所植物分子生物学硕士学位，1998年获美国California Institute of Technology遗传学博士学位，1998-2001年为Whitehead Institute, MIT博士后，2001-2008年为美国康奈尔大学植物生物学系助理教授，2008年晋升为副教授，兼任康奈尔大学植物生物学领域研究生学习的主任。
华健副教授攻读博士学位期间主要从事乙烯受体基因鉴定及其信号传导途径解析方面的研究，后来重点研究环境对植物细胞坏死、生长发育以及植物抗病和防卫反应的影响分子机理。研究结果已经在Cell，Science，Genes and Development，Plant Cell，PNAS，PLoS Pathogen，Current Opinion in Plant Biology，Plant Journal，Plant Physiology等国际顶尖学术期刊发表系列论文。
部分论文：
Bao, Z., Yang, H., & Hua, J. (2013). Perturbation of cell cycle regulation triggers plant immune response via activation of disease resistance genes. Proceedings of the National Academy of Sciences of the United States of America. 110(6):2407-12
Zhu, Y., Du, B., Qian, J., Zou, B., & Hua, J. (2013). Disease resistance gene-induced growth inhibition is enhanced by rcd1 independent of defense activation in Arabidopsis.. Plant Physiology. 161:2005-13.
Mingyue, G., Zhenying, S., Ying, Z., Zhilong, B., Guoying, W., & Hua, J. (2012). The F-box protein CPR1/CPR30 negatively regulates R protein SNC1 accumulation. Plant Journal. 69:411-420.
Zhu, Y., Mang, H., Sun, Q., Hipps, A., & Hua, J. (2012). Gene discovery using mutagen-induced polymorphisms and deep sequencing: application to plant disease resistance. Genetics. 192:139-146.
Mang, H., Qian, W., Zhu, Y., Qian, J., Kang, H., Klessig, D. F., & Hua, J. (2012). ABA deficiency antagonizes high temperature inhibition of disease resistance through enhancing nuclear accumulation of R proteins SNC1 and RPS4. Plant Cell. 24:1271-1284.
Zhu Y, Yang H, Mang HG, and Hua J (2011) Induction of BAP1 by a moderate decrease in temperature is mediated by ICE1 in Arabidopsis. Plant Physiol, 155, in press.
Zhu Y, Qian W, Hua J (2010) Temperature modulates plant defense responses through NB-LRR Proteins. PLoS Pathog 6(4): e1000844.
Li Y, Gou M, Sun Q, and Hua J (2010) Requirement of calcium binding, myristoylation, and protein-protein interaction for the copine BON1 function in Arabidopsis. J Biol Chem, 285, 29884-29891.
Wang Y, Hua J. (2009) A moderate decrease in temperature induces COR15a expression through the CBF signaling cascade and enhances freezing tolerance. Plant J. 60, 340-349
Li Y, Pennington BO, Hua J. (2009) Multiple R-like genes are negatively regulated by BON1 and BON3 in Arabidopsis. MPMI 22:840-848.
Wang Y, Bao Z, Zhu Y, Hua J. (2009) Analysis of temperature modulation of plant defense against biotrophic microbes. MPMI 22:498-506.
Yang H, Yang S, Li Y, Hua J. (2007) The Arabidopsis BAP1 and BAP2 genes are general inhibitors of programmed cell death. Plant Physiol. 145, 135-46.
Li Y, Yang S, Yang H, and Hua J. (2007) The TIR-NB-LRR gene SNC1 is regulated at the transcript level by multiple factors MPMI 20:144956.
Yang H, Li Y, Hua J. (2006) The small C2 protein BAP1 negatively regulates cell death and defense response in Arabidopsis. Plant J, 48: 238-48.
Yang S, Yang H, Grisafi P, Sanchatjate S, Fink GR, Sun Q, Hua J. (2006) The BON/CPN gene family represses cell death and promotes cell growth in Arabidopsis. Plant J, 45:166-79.
Yang S, Hua J. (2004) A haplotype-specific Resistance gene regulated by BON1 mediates temperature-dependent growth control. Plant Cell, 16:1060-71
Hua J, Grisaffi P, Cheng, SH, Fink GR. (2001) Plant growth homeostasis is controlled by the Arabidopsis BON1 and BAP1 genes. Genes Dev, 15:2263-2272.
Hua J, Meyerowitz EM. (1998) Ethylene responses are negatively regulated by a receptor gene family. Cell, 94:261-71
Hua J, Sakai H, Chen QG, Nourizadeh S, Bleecker AB, Ecker JR, Meyerowitz EM. (1998) EIN4 and ERS2 are two members of the putative ethylene receptor gene family. Plant Cell, 10:1321-32.
Sakai H, Hua J, Chen QG, Chang C, Mderano L, Bleecker AB, Meyerowitz EM. (1998) ETR2 is an ETR1-like gene involved in ethylene signaling in Arabidopsis. PNAS, 95:5812-7.
Hua J, Chang C, Sun Q, Meyerowitz EM. (1995) Ethylene insensitivity conferred by Arabidopsis ERS gene. Science, 269:1712-4.
