报告题目：Viral manipulation of plant defensive signal transduction pathways
报告人：John P. Carr博士
报告时间：2010年9月20日(周一)下午2：30
报告地点：华家池校区团结馆二楼212多媒体教室
联系人：梁五生（13656811708）
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浙大农学院生物所
2010年9月14日
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报告人简介：
John P. Carr博士现为英国剑桥大学植物科学系高级讲师，分子植物病毒学研究组负责人。他主要研究植物与病原物的互作机理，尤其是关于植物对病毒的诱导抗性和病毒对植物防卫系统的反调控机理研究，是目前国际上该领域较活跃的专家之一。目前担任MPMI的Senior Editor。迄今已在Science、Plant Cell、Plant Journal、Plant Physiology、MPMI等学术刊物上发表论文近四十篇。
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Virology and Molecular Plant Pathology
We are interested in the interactions of plants with pathogens and pests, why some plants actively resist their attackers, and how some pathogens manipulate the resistance responses of plants.
Resistance
Our work on resistance for the most part focuses on the effects of the naturally occurring plant 'alarm' molecule, salicylic acid (SA: the chemical parent of aspirin) on plant-infecting viruses, and how this defence system works together with anti-viral RNA silencing. Meanwhile, in collaboration with Dr. David Hanke we are also characterizing an SA-independent signaling system regulated by myo-inositol 6-phosphate that regulates resistance to viruses, bacteria and fungi.
Manipulation of resistance signaling pathways by a viral pathogen
Our work on the subversion and manipulation of plant responses to attack centers on a counter-defence factor and inhibitor of RNA silencing made by Cucumber mosaic virus (CMV) called the 2b protein. We found that the 2b protein inhibits changes in plant gene expression induced by jasmonate, a key signal in plant resistance to insects. Additional experiments suggested that the virus- through the activity of the 2b protein- is able to manipulate plant defensive signalling and metabolism so that the host plant's interactions with aphids will serve to enhance persistence and transmission of the virus.
