Current Position : homepage  Home.  News

Ph.D. student Lin Lin from College of Agriculture and Biotechnology identified a novel DqsIR Quorum sensing of Deinococcus radiodurans in response to extreme stresses

Date:2016-03-21 Hits:198

Deinococcus radiodurans is known for its cellular resistance to environmental stresses including radiation and oxidants. It was used as a model system for study on interaction mechanisms of organisms and extreme environment, and evolution of organisms. Previous studies on the resistant mechanism of D. radiodurans focus on intracellular resistant systems and DNA repair system.
The recent work of Ph.D. student Lin Lin from College of Agriculture and Biotechnology identified a novel DqsIR Quorum sensing of D. radiodurans in response to extreme stresses. The DqsIR Quorum sensing was employed by D. radiodurans in response to oxidative stress .The results has been published online (Molecular Microbiology, doi: 10.1111/mmi.13331). Prof. Bing Tian and Prof. Yuejin Hua are the corresponding authors for this work.
D. radiodurans has novel acyl-homoserine lactones (AHL) synthases, refer to as DqsI-1 and DqsI-2, which are different from either the LuxI or LuxM families.Upon exposure to H2O2, AHL synthetic enzymes (DqsI) were immediately induced, resulting in accumulation of AHLs which were used as the cell to cell communication signals. These results indicated that AHL production in D. radiodurans is oxidative stress-dependent. The DqsR, acting as a regulator of quorum sensing,controls gene expression level along with AHLs. Hence,the DqsIR-mediated quorum sensing might be a strategy for D. radiodurans in response to oxidative stresses and is conserved in the extremophilic Deinococcus bacteria.
  (Institution of Nuclear-Agricultural Science)

Proposed DqsIR quorum-sensing pathway in D. radiodurans