Title:
See Protein in Action Using Infrared Structural Biology
Lecturer:
Prof. Xie Aihua, Department of Physics, Oklahoma State University, USA
Time:
9:00A.M.June 30, 2014
Venue:
Room A117, College of Agriculture and Biotechnology
Abstract：
Proteins are dynamic. Lack of technology to detect functionally important structural motions of proteins hinders our understanding of protein functions. Advancing technology often catalyzes new scientific discoveries and pushes the boundary of unknown. I will report an emerging technology: time-resolved infrared structural biology that has excellent time resolution and high structural sensitivity. Thus it is ideally suitable to probe the functionally important structural motions of proteins, including proton transfer, hydrogen-bond dynamics, and protein quakes. I will show that how time-resolved infrared structural biology is employed to study the “electrostatic epicenter” for protein quake and receptor activation in biological signaling using photoactive yellow protein.