Autophagy： Rice black-streaked dwarf virus P10 promotes phosphorylation of GAPDH (glyceraldehyde-3-phosphate dehydrogenase) to induce autophagy in Laodelphax striatellus

Ricevirusesareprevalentinmanyrice-growingcountriesandoftencauseseriousdamagestoriceproduction.Riceblack-streakeddwarfvirus(RBSDV),amemberofthegenusFijivirusoffamilyReoviridae,isoneofdestructiveplantvirusesthatcausesmassivelossofriceyieldeachyear.OnJuly27,2021,theresearchteamledbyProf.WuJianxianginInstituteofBiotechnology,ZhejiangUniversity,publishedanarticletitled“Riceblack-streakeddwarfvirusP10promotesphosphorylationofGAPDH(glyceraldehyde-3-phosphatedehydrogenase)toinduceautophagyinLaodelphaxst

【2021-07-28】 More

A report of geminivirus encoded βC1 protein interfering host MAPK cascade mediated defense by concertedly targeting MKK2 and MPK4

GeminivirusesareagroupofDNAvirusesthatinfectimportantcropstocauseseriousdamagesinagricultureandleadtoagreateconomiclossworldwide.Betasatellite(DNAβ)isaclassofsingle-strandedcircularDNAmoleculesthatisassociatedwithmonopartitegeminivirusestoinducedevastatingdiseases.Sofar,ithasbeenrecognizedthatDNAβencodesaviralproteinβC1onthecomplementarystrand,whichisapathogenicfactorthatinterferesmultipleplantdevelopmentanddefenseprocesses.OnApril18th,acollaborateworkfromDr.XuepingZhou’steam(ZhejiangUniversity,

【2019-04-20】 More

PLOS PATHOGENS: The MAPK kinase BcMkk1 suppresses oxalic acid biosynthesis via impeding phosphorylation of BcRim15 by BcSch9 in Botrytis cinerea

TheMAPKkinaseBcMkk1suppressesoxalicacidbiosynthesisviaimpedingphosphorylationofBcRim15byBcSch9inBotrytiscinereaYanniYin,SisiWu,ChaonanChui,TianlingMa,HuixianJiang,MatthiasHahn,ZhonghuaMaAbstractThemitogen-activatedproteinkinase(MAPK)cassetteofthecellwallintegrity(CWI)pathwayisprimarilyresponsiblefororchestratingchangesofcellwall.However,functionsofthiscassetteinothercellularprocessesarenotwellunderstood.Here,wefoundthattheBotrytiscinereamutantofMAPKkinase(BcMkk1)displaysmoreseriousdefectsinmycel

【2018-09-15】 More

Nature communications：Wheat microbiome bacteria can reduce virulence of a plant pathogenic fungus by altering histone acetylation

WheatmicrobiomebacteriacanreducevirulenceofaplantpathogenicfungusbyalteringhistoneacetylationYunChen,JingWang,NanYang,ZiyueWen,XuepengSun,YunrongChaiZhonghuaMaAbstractInteractionsbetweenbacteriaandfungihavegreatenvironmental,medical,andagriculturalimportance,butthemolecularmechanismsarelargelyunknown.Here,westudytheinteractionsbetweenthebacteriumPseudomonaspiscium,fromthewheatheadmicrobiome,andtheplantpathogenicfungusFusariumgraminearum.Weshowthatacompoundsecretedbythebacteria(phenazine-1-carbox

【2018-08-27】 More

New Phytologist:The ATP-binding protein FgArb1 is essential for penetration, infectious and normal growth of Fusarium graminearum

TheATP-bindingproteinFgArb1isessentialforpenetration,infectiousandnormalgrowthofFusariumgraminearum

【2018-07-15】 More

PLOS PATHOGENS: The fungal myosin I is essential for Fusarium toxisome formation

AbstractMyosin-Imolecularmotorsareproposedtofunctionaslinkersbetweenmembranesandtheactincytoskeletoninseveralcellularprocesses,buttheirroleinthebiosynthesisoffungalsecondarymetabolitesremainelusive.Here,wefoundthatthemyosinIofFusariumgraminearum(FgMyo1),thecausalagentofFusariumheadblight,playscriticalrolesinmycotoxinbiosynthesis.InhibitionofmyosinIbythesmallmoleculephenamacrilleadstomarkedreductionindeoxynivalenol(DON)biosynthesis.FgMyo1alsogovernstranslationoftheDONbiosyntheticenzymeTri1byinter

【2018-07-15】 More

PLOS PATHOGENS: Tomato leaf curl Yunnan virus-encoded C4 induces cell division through enhancing stability of Cyclin D 1.1 via impairing NbSKη-mediated phosphorylation in Nicotiana benthamiana

AbstractThewhitefly-transmittedgeminivirusesinduceseveredevelopmentalabnormalitiesinplants.Geminivirus-encodedC4proteinfunctionsasoneofviralsymptomdeterminantsthatcouldinduceabnormalcelldivision.However,themolecularmechanismbywhichC4contributestocelldivisioninductionremainsunclear.HerewereportthattomatoleafcurlYunnanvirus(TLCYnV)C4interactswithaglycogensynthasekinase3(GSK3)/SHAGGY-likekinase,designedNbSKη,inNicotianabenthamiana.Pro32,Asn34andThr35ofTLCYnVC4arecriticalforitsinteractionwithNbSKηan

【2018-07-15】 More

Annual Review of Phytopathology: Developments in Plant Negative-Strand RNA Virus Reverse Genetics

AbstractTwentyyearsago,breakthroughsforreversegeneticsanalysesofnegative-strandRNA(NSR)viruseswereachievedbydevisingconditionsforgenerationofinfectiousvirusesinsusceptiblecells.RecombinantstrategieshavesubsequentlybeenengineeredformembersofallvertebrateNSRvirusfamilies,andresearcharisingfromtheseadvanceshasprofoundlyincreasedunderstandingofinfectioncycles,pathogenesis,andcomplexitiesofhostinteractionsofanimalNSRviruses.Thesestrategiesalsopermitteddevelopmentofmanyapplications,includingattenuated

【2018-07-15】 More

The ISME Journal: Multi-omics analysis of niche specificity provides new insights into ecological adaptation in bacteria

Multi-omicsanalysisofnichespecificityprovidesnewinsightsintoecologicaladaptationinbacteriaBoZhu,MuhammadIbrahim,ZhouqiCui,GuanlinXie,GuleiJin,MichaelKube,BinLiXuepingZhouAbstractDifferentlifestyles,rangingfromasaprophytetoapathogen,havebeenreportedinbacteriaofonespecies.Here,weperformedgenome-widesurveyoftheecologicaladaptationinfourBurkholderiaseminalisstrains,distinguishedbytheiroriginaspartofthesaprophyticmicrobialcommunityofsoilorwaterbutalsoincludinghumanandplantpathogens.Theresultsindicate

【2018-07-14】 More

PLOS PATHOGENS: Rescue of a Plant Negative-Strand RNA Virus from Cloned cDNA: Insights into Enveloped Plant Virus Movement and Morphogenesis

RescueofaPlantNegative-StrandRNAVirusfromClonedcDNA:InsightsintoEnvelopedPlantVirusMovementandMorphogenesisQiangWang,XiaonanMa,ShaShaQian,XinZhou,KaiSun,XiaolanChen,XuepingZhou,AndrewO.Jackson,ZhengheLiAbstractReversegeneticssystemshavebeenestablishedforallmajorgroupsofplantDNAandpositive-strandRNAviruses,andourunderstandingoftheirinfectioncyclesandpathogenesishasbenefittedenormouslyfromuseoftheseapproaches.However,technicaldifficultieshaveheretoforehamperedapplicationsofreversegeneticstoplantne

【2018-07-13】 More

New Phytologist: The AC5 protein encoded by Mungbean yellow mosaic India virus is a pathogenicity determinant that suppresses RNA silencing‐based antiviral defenses

TheAC5proteinencodedbyMungbeanyellowmosaicIndiavirusisapathogenicitydeterminantthatsuppressesRNAsilencing‐basedantiviraldefensesFangfangLiXiongbiaoXuChangjunHuangZhouhangGuLingeCaoTaoHuMingDingZhengheLiXuepingZhouSummaryItisgenerallyacceptedthatbegomovirusesinthefamilyGeminiviridaeencodefourproteins(fromAC1/C1toAC4/C4)usingthecomplementary‐senseDNAastemplate.AlthoughAC5/C5codingsequencesareincreasinglyannotatedindatabasesformanybegomoviruses,theevolutionaryrelationshipsandfunctionsofthisputative

【2018-07-12】 More

New Phytologist: Functional analysis of the Fusarium graminearum phosphatome

FunctionalanalysisoftheFusariumgraminearumphosphatomeYingziYunZunyongLiuYanniYinJinhuaJiangYunChenJin‐RongXuZhonghuaMaSummaryPhosphatasesareknowntoplayimportantrolesintheregulationofvariouscellularprocessesineukaryotes.However,systematiccharacterizationofthephosphatomehasnotbeenreportedinphytopathogenicfungi.ThewheatscabfungusFusariumgraminearumcontains82putativephosphatases.Thebiologicalfunctionsofeachphosphatasewereinvestigatedinthisstudy.Although11phosphatasegenesappearedtobeessential,deletio

【2018-07-11】 More

PLOS PATHOGENS: Suppression of RNA Silencing by a Plant DNA Virus Satellite Requires a Host Calmodulin-Like Protein to Repress RDR6 Expression

SuppressionofRNASilencingbyaPlantDNAVirusSatelliteRequiresaHostCalmodulin-LikeProteintoRepressRDR6ExpressionFangfangLi,ChangjunHuang,ZhengheLi,XuepingZhouAbstractInplants,RNAsilencingplaysakeyroleinantiviraldefense.Tocounteracthostdefense,plantvirusesencodeviralsuppressorsofRNAsilencing(VSRs)thattargetdifferenteffectormoleculesintheRNAsilencingpathway.EvidencehasshownthatplantsalsoencodeendogenoussuppressorsofRNAsilencing(ESRs)thatfunctioninproperregulationofRNAsilencing.Thepossibilitythatthesec

【2018-07-10】 More