Pesticide & Environmental Endocrine Disrupting Effects and Molecular Mechanisms

发布者:农药与环境毒理研究所发布时间:2018-06-20浏览次数:98

Our research group is interested in pesticide & environmental endocrine disrupting effects and molecular mechanisms over the years. The endocrine disrupting effects we are focusing on are the Hypothalamus-Pituitary-Thyroid (HPT) axisHypothalamus-Pituitary- Gonad (HPG) axis and neurosystem disruptions brought by pesticides and other environmental chemical contaminants in low dose-long term exposure. The in vivo and in vitro evaluation systems are being used, e. g., H295R cell line, zebrafish (Danio rerio) and frog (Xenopus laevis), etc. The main approaches we are using involve GC, HPLC, GC- and LC-MS/MS, Molecular Docking, SPR, RT-PCR and genome-wide transcriptomic analyses, etc. We are extending our research to other relevant research fields, such like QSAR of pesticides and environmental endocrine disrupting effects, developing biomarkers for early warning for the aquatic environments and pesticide environmental fate.

In recent years, we have been funded by the several grants, e. g., two general programs (2016-2019 and 2017-2020) from National Natural Science Foundation of China, a key project (2018-2021) and a general program (2012-2014) from Zhejiang Natural Science Foundation, a project (2011-2014) from Zhejiang Innovative Team Foundation and a program (2012-2014) from Foundation of Ministry of Education of China, etc. We also have carried out cooperative studies with several famous international and domestic enterprises (such as Bayer, Dow, BASF and so on)on ecotoxicity evaluation of artificially synthesized chemicals, environmental behavior test of pesticides, and more than 50 joint projects have been successfully accomplished.