High yield and early-ripe traits are always main breeding targets for vegetable crops, and have been clearly improved through classic genetic approaches. To achieve a higher level of breeding improvement, we urgently need to discover breakthrough in germplasm innovation for the complex traits. Recently, a collaborative project between the Institute of Vegetable Science at Zhejiang University and the Plant Innovation Center at the University of Nebraska-Lincoln demonstrate that MSH1 suppression and subsequent breeding programs result in earlier ripening, high yields and heat tolerance in tomato. This enhancement in growth appear to graft-transmissible indicating it giant potentials in breeding.