CURRICULUM VITAE

Dr. Yun Chen

Associate Professor

Institute of Biotechnology, Zhejiang University

866 Yuhangtang Road, Hangzhou, Zhejiang, 310058, China

Tel: 86-517-88982106

Email: chenyun0927@zju.edu.cn

Academic Education

Ph.D. in Plant pathology, Nanjing Agricultural University (2007/09-2012/12)

Jointed -Ph.D. in Molecular and cellular biology, Harvard University (2010/08-2012/09)

B.S. in Plant Protection, Nanjing Agricultural University (2003/09-2007/06)

Appointment

Institute of Biotechnology, Zhejiang University, Assistant Professor

 (2013/01- 2014/12)

Institute of Biotechnology, Zhejiang University, Associate Professor

 (2014/12- Present)

Research Interests

1. Fungal biology. Fusarium graminearum is a destructive pathogenic fungus that widely causes wheat head blight in China. The disease can result in severe direct yield losses and wheat quality reduction by mycotoxin. Our group is interested in understanding the pathogenic mechanisms of F. graminearum and this disease management with integrated approaches including with chemical fungicides, biocontrol agents and agricultural measures.

2. Bacteria-fungi interaction. Physical and metabolic interactions between bacteria and fungi are widespread in nature and have great environmental, medical and agricultural importance. Yet, the underlying mechanisms are largely unknown. In our lab, we use the bacterial biocontrol agents vs the plant pathogenic fungus Fusarium graminearum as a model to investigate the molecular details between the bacterial-fungal interaction.

3. Biological function of microbial biofilm.

Publications:

1)Guangfei Tang, Chengqi Zhang, Zhenzhen Ju, Shiyu Zheng, Ziyue Wen, Sunde Xu, Yun Chen*and Zhonghua Ma. The mitochondrial membrane protein FgLetm1 regulates mitochondrial integrity, production of endogenous reactive oxygen species and mycotoxin biosynthesis in Fusarium graminearum. Molecular Plant Pathology. onlinelibrary.wiley.com/doi/10.1111/mpp.12633/full.（5-yr IF=5.272)

2)Sunde Xu, Nan Yang, Shiyu Zheng, Fang Yan, Chunhao Jiang, Yiyang Yu, Jianhua Guo, Yunrong Chai, Yun Chen*. The spo0A-sinI-sinR regulatory circuit plays an essential role in biofilm formation, nematicidal activities, and plant protection in Bacillus cereus AR156.Molecular Plant-Microbe Interactions. 30(8):603-619, 2017.（5-yr IF=4.598)

3)Fang Yan, Yiyang Yu, Kevin Gozzi, Yun Chen, Jian-hua Guo, Yunrong Chai. Genome-Wide Investigation of Biofilm Formation in Bacillus cereus.Applied and Environmental Microbiology. 83 (13),e00561-17, 2017.（5-yr IF=4.282)

4)Zunyong Liu, Sisi Wu, Yun Chen, Xinyue Han, Qin Gu, Yanni Yin, Zhonghua Ma. The microtubule end‐binding protein FgEB1 regulates polar growth and fungicide sensitivity via different interactors in Fusarium graminearum. Environmental microbiology. 19(5),1791-1807, 2017. (5-yr IF=6.78)

5)Yun Chen, Kevin Gozzi, Fang Yan, Yunrong Chai. Acetic acid acts as a volatile signal to stimulate bacterial biofilm formation. Mbio.6(3) e00392-15, 2015.（5-yr IF=7.165)

6)Yun Chen, Qixun Gao, Mengmeng Huang, Ye Liu, Zunyong Liu, Xin Liu & Zhonghua Ma. Characterization of RNA silencing components in the plant pathogenic fungus Fusarium graminearum. Sci. Rep. 5, 12500; doi: 10.1038/srep12500, 2015. （5-yr IF=5.597)

7)Qin Gu*, Yun Chen*, Ye Liu, Chengqi Zhang, and Zhonghua Ma. The transmembrane   

protein FgSho1 regulates fungal development and pathogenicity via the MAPK module Ste50-Ste11-Ste7 in Fusarium graminearum. NewPhytologist. 26(1), 315-328, 2015.(5-yr IF=7.2）(Co-first author)

8)Yingzi Yun, Zunyong Liu, Yanni Yin, Jinhua Jiang, Yun Chen, Jin-Rong Xu, Zhonghua Ma. Functional analysis of the Fusarium graminearum phosphatome. New Phytologist. 207(1):119-134,2015. (5-yr IF=7.2）

9)Ye Liu, Na Liu, Yanni Yin, Yun Chen, Jinhua Jiang, Zhonghua Ma. Histone H3K4 methylation regulates hyphal growth, secondary metabolism and multiple stress responses in Fusarium graminearum. Environmental microbiology. 17(11), 4615-4630, 2015.

10)Chengqi Zhang*, Yun Chen*, Yanni Yin, Huanhong Ji, Won-Bo Shim, Yiping Hou, Mingguo Zhou, Xiang-dong Li, and Zhonghua Ma. A small molecule species-specifically inhibits Fusarium myosin I. Environmental Microbiology,DOI: 10.1111/1462-2920.12711. 2014.(5-yr IF=6.78) (Co-first author)

11)Weiqun Hu, Qixun Gao, Mohamed Sobhy Hamada, Dawood Hosni Dawood, Jingwu Zheng, Yun Chen*, Zhonghua Ma. Potential of Pseudomonaschlororaphis subsp. aurantiaca strain Pcho10 as a biocontrol agent against Fusarium graminearum. Phytopathology. 104(12): 1289-1297.2014.(5-yr IF=3.02）

12)Yingzi Yun, Dafang Yin, Xin Liu, Yun Chen*, Zhonghua Ma. Functional characterization of      FgERG3 and FgERG5 associated with ergosterol biosynthesis, vegetative differentiation and   virulence of Fusarium graminearum. Fungal Genetics and Biology. 68:60-70, 2014. (5-yr IF=3.379）

13)Arvind R Subramaniam, Aaron DeLoughery, Niels Bradshaw, Yun Chen, Erin O’Shea, Richard Losick, Yunrong          Chai. A serine sensor for multicellularity in a bacterium. eLife.2:e01501. 2013. (5-yr        IF=8.556）

14)Yingzi Yun,Zunyong Liu, Jingze Zhang, Won-Bo Shim, Yun Chen and Zhonghua Ma. The MAPKK FgMkk1 of Fusarium graminearum regulates vegetative differentiation, multiple stress response, and virulence via the cell wall integrity andhigh-osmolarity glycerol signaling pathways. Environmental Microbiology.16(7):2023-2037.2013. (5-yr IF=6.78)

15)Chen Yun, Yan Fang, Chai Yunrong, Liu Hongxia, Kolter Roberto, Losick Richard, Guo Jianhua.Biocontrol of tomato wilt disease by Bacillus subtilis isolates from natural environments depends on conserved genes mediating biofilm formation. Environmental Microbiology.15(3):848-864. 2013. (5-yr IF=6.78)

16)Chen Yun, Cao Shugeng, Chai Yunrong, Clardy Jon, Kolter Roberto, Guo Jianhua, Losick 

Richard. A Bacillus subtilis sensor kinase involved in triggering biofilm formation on the roots of tomato plants. Molecular Microbiology. 85(3),418–430. 2012. (5-yr IF=5.05)

17)Chen Yun, Chai Yunrong, Guo Jianhua, Losick Richard. Evidence for cyclic di-GMP-mediated signaling in Bacillus subtilis. Journal of Bacteriology. 194: 5080-5090. 2012. (5-yr IF=3.298)

18)Chen Yun, Zhang Wenzhi, Liu Xin, Ma Zhonghua, Li Bo, Allen Caitilyn, GuoJianhua. A Real-Time PCR Assay for the Quantitative Detection of Ralstonia solanacearum in Horticultural Soil and Plant Tissues. Journal of Microbiology Biotechnology. 20（1）:193–201.2010. (5-yr IF=1.481)

2.Patent：

1)Yun Chen,Yanni Yin, Zhonghua Ma, 2017, 201510104337.1

2)Yun Chen,Yanni Yin, Zhonghua Ma, 2015, ZL201310351388.5

3)Yun Chen,Yanni Yin, Zhonghua Ma, 2015, ZL201310755168.9

4)Yun Chen,Yanni Yin, Zhonghua Ma, 2015, ZL201310351909.7

5)Yun Chen,Yanni Yin, Zhonghua Ma, 2015, ZL201310493822.3

6)Yanni Yin, Yun Chen, Zhonghua Ma,2015, ZL201310494922.8

7)Jianhua Guo,Chunhao Jiang,Yun Chen,2011,ZL201110004936.8

8)Jianhua Guo,Dongmei Zhou,Wenzhi Zhang,Yun Chen, 2011,ZL201110074336.9

9)Jianhua Guo,Yun Chen, Yan Fang,Mingming Yang,2010,ZL201010608662.9

10)Jianhua Guo,Shimo Li,Yun Chen,2010,ZL201010125070.1

11)Jianhua Guo,Hongxia Liu,Lihui Wei,Yun Chen,2009,ZL200910184045.8.