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CURRICULUM VITAE

日期:2017-11-06

CURRICULUM  VITAE

Professor Xin-Zhong Cai

  

Contact Information

Institute of Biotechnology

College of Agriculture and Biotechnology

Zhejiang University, Zi Jin Gang Campus

866 Yu Hang Tang Road

Hangzhou 310058

P.R.China

Tel: +86 571 88982936

Email: xzhcai@zju.edu.cn

  

  

Honorary titles

New Century Excellent Talent, the Ministry of Education

New Century 151 Talent, Zhejiang province

Distinguished Youth Scholar, Zhejiang province

Education

1987.9-1991.7, BSc of plant protection, Zhejiang Agricultural University, Hangzhou, P.R.China

1991.9-1994.7,  MSc of plant pathology, Zhejiang Agricultural University, Hangzhou, P.R.China

1996.9-2001.3, PhD of plant pathology, Zhejiang University, Hangzhou, P.R.China

  

  

Professional Experiences

1994.8-1997.8, Teaching Assistant of plant pathology, Department of Plant Protection, Zhejiang Agricultural University, Hangzhou, P.R.China

1997.9-2001.11, Lecturer of plant pathology, Department of Plant Protection, Zhejiang University, Hangzhou, P.R.China

1998.5-2000.11, Visiting scholar of plant pathology, Laboratory of Phytopathology, Wageningen University, Wageningen, the Netherlands

2001.12-2006.11, Associate Professor of plant pathology, Institute of Biotechnology, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou, P.R.China

2006.12-present, Professor of plant pathology, Institute of Biotechnology, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou, P.R.China

  

  

Areas of Specialization

Molecular biology and gene engineering of plant disease resistance, with focus on

Ca2+ signaling and RNA silencing and their roles in plant defense;

Molecular interactions between plants and Sclerotinia sclerotiorum;

Nonhost resistance to Xanthomonas oryzae pv. oryzae

  

  

Projects and Funds

Efficient and safe target screening and RNAi functional mechanisms. National Key Research and Development Project (no. 2017YFD0200904), 2017.7-2020.12

Dissection of functions and mechanisms of oilseed rape CAMTA3 in resistance to Sclerotinia sclerotiorum. National Natural Science Foundation of China (no. 31672014), 2017.1-2020.12

Functional analyses of oilseed rape CNGC genes in resistance to Sclerotinia sclerotiorum. Zhejiang Provincial Natural Science Foundation of China (no. LZ18C140002), 2018.1-2021.12

Exploration and functional analyses of novel regulatory genes of rice bacterial diseases. Genetically Modified Organisms Breeding Major Projects (no. 2014ZX0800905B). 2014.1-2016.12

  

  

Publications:

Li W, Cao JY, Xu YP, Cai XZ*. Artificial Agrobacterium tumefaciens strains exhibit diverse mechanisms to repress Xanthomonas oryzae pv. oryzae-induced hypersensitive response and nonhost resistance in Nicotiana benthamiana. Molecular Plant Pathology, 2017, 18(4): 489–502. DOI: 10.1111/mpp.12411

Cao JY, Xu YP, Zhao L, Li SS, Cai XZ*. Tight regulation of the interaction between Brassica napus and Sclerotinia sclerotiorum at the microRNA level. Plant Molecular Biology, 2016, 92(1): 39-55. DOI: 10.1007/s11103-016-0494-3

Cao JY, Xu YP, Li W, Li SS, Rahman H, Cai XZ*. Genome-wide identification of Dicer-like, Argonaute and RNA-dependent RNA polymerase gene families in Brassica species and functional analyses of their Arabidopsis homologs in resistance to Sclerotinia sclerotiorum. Frontiers in Plant Science, 2016, 7: 1614. doi: 10.3389/fpls.2016.01614

Rahman H, Xu YP, Zhang XR, Cai XZ*. Brassica napus genome possesses extraordinary high number of CAMTA genes and CAMTA3 contributes to PAMP triggered immunity and resistance to Sclerotinia sclerotiorum. Frontiers in Plant Science, 2016, 7: 581. doi: 10.3389/fpls.2016.00581

Cao JY, Xu YP, Cai XZ*. TMT-based quantitative proteomics analyses reveal novel defense mechanisms of Brassica napus against the devastating necrotrophic pathogen Sclerotinia sclerotiorum. Journal of Proteomics, 2016, 143: 265-277. DOI: 10.1016/j.jprot.2016.03.006

Munyampundu JP, Xu YP, Cai XZ*. Phi class of glutathione S-transferase gene superfamily widely exists in non-plant taxonomic groups. Evolutionary Bioinformatics, 2016, 12: 59–71. DOI: 10.4137/EBO.S35909

Rahman H, Yang J, Xu YP, Munyampundu JP, Cai XZ*. Phylogeny of plant CAMTAs and role of AtCAMTAs in nonhost resistance to Xanthomonas oryzae pv. oryzae. Frontiers in Plant Science, 2016, 7: 177. doi: 10.3389/fpls.2016.00177

Li W, Xu YP, Cai XZ*. Transcriptional and posttranscriptional regulation of the tomato leaf mould disease resistance gene Cf-9. Biochemical and Biophysical Research Communications, 2016, 470: 163-167. DOI: 10.1016/j.bbrc.2016.01.015

Wang JP, Munyampundu JP, Xu YP, Cai XZ*. Phylogeny of plant calcium and calmodulin-dependent protein kinases (CCaMKs) and functional analyses of tomato CCaMK in disease resistance. Frontiers in Plant Science, 2015, 6: 1075. doi: 10.3389/fpls.2015.01075

Wang JP, Xu YP, Zang XP, Li SS, Cai XZ*.Sclerotinia sclerotiorum virulence is affected by mycelial age via reduction in oxalate biosynthesis. Journal of Integrative Agriculture, 2016, 15(5): 1034-1045. Doi: 10.1016/S2095-3119(15)61199-6

Wang JP, Xu YP, Munyampundu JP, Liu TY, Cai XZ*. Calcium-dependent protein kinase (CDPK) and CDPK-related kinase (CRK) gene families in tomato: genome-wide identification and functional analyses in disease resistance. Molecular Genetics and Genomics, 2016, 291(2): 661–676. DOI 10.1007/s00438-015-1137-0

Qian Y, Hou H, Shen Q, Cai XZ, Sunter G and Zhou X*. RepA protein encoded by Oat dwarf virus elicits a temperature-sensitive hypersensitive response-type cell death that involves jasmonic acid-dependent signaling. Molecular Plant-Microbe Interactions, 2016, 29(1): 5-21. DOI: 10.1094/MPMI-07-15-0149-R

Saand MA, Xu YP, Munyampundu JP, Li W, Zhang XR, Cai XZ*. Phylogeny and evolution of plant cyclic nucleotide-gated ion channel (CNGC) gene family and functional analyses of tomato CNGCs. DNA Research, 2015, 22(6): 471–483. doi: 10.1093/dnares/dsv029

Li W, Xu YP, Munyampundu JP, Xu X, Qi XF, Gu Y, Cai XZ*. Functional identification of phenazine biosynthesis genes in plant pathogenic bacteria Pseudomonas syringae pv. tomato and Xanthomonas oryzae pv. oryzae. Journal of Integrative Agriculture, 2016, 15(4): 812–821. Doi:10.1016/S2095-3119(15)61176-5

Li, W., Xu, Y.P., Yang, J., Chen, G.Y. and Cai, X.Z.*. Hydrogen peroxide is indispensable to Xanthomonas oryzae pv. oryzae-induced hypersensitive response and nonhost resistance in Nicotiana benthamiana. Australasian Plant Pathology, 2015, 44: 611–617. DOI 10.1007/s13313-015-0376-1

Saand, M.A., Xu, Y.P., Li, W., Wang, J.P. and Cai, X.Z.*. Cyclic nucleotide gated channel gene family in tomato: genome-wide identification and functional analyses in disease resistance. Frontiers in Plant Science, 2015, 6: 303. doi:10.3389/fpls.2015.00303

Zhao Y, Liu W, Xu YP, Cao JY, Braam J, Cai XZ*. Genome-wide identification and functional analyses of calmodulin genes in Solanaceous species. BMC Plant Biology, 2013, 13:70. DOI: 10.1186/1471-2229-13-70

Xu QF, Cheng WS, Li SS, Li W, Zhang ZX, Xu YP, Zhou X, Cai XZ*. Identification of genes required for Cf-dependent hypersensitive cell death by combined proteomics and RNA interfering analyses. Journal of Experimental Botany, 2012, 63(7): 2421-2435. doi: 10.1093/jxb/err397

Li W, Xu YP, Zhang ZX, Cao WY, Li F, Zhou X, Chen GY, Cai XZ*. Identification of genes required for nonhost resistance to Xanthomonas oryzae pv. oryzae reveals novel signaling components. PLoS ONE, 2012, 7(8): e42796. doi:10.1371/journal.pone.0042796

Xu YP, Chen HY, Zhou X, Cai XZ*. Induction of hypersensitive response and nonhost resistance by a Cladosporium fulvum elicitor CfHNNI1 is dose-dependent and negatively regulated by salicylic acid. Journal of Integrative Agriculture, 2012, 11(10): 1665-1674. 

Xu YP, Zheng LP, Xu QF, Wang CC, Zhou XP, Wu ZJ, and Cai XZ*. Efficiency for gene silencing induction in Nicotiana species by a viral satellite DNA vector. Journal of Integrative Plant Biology2007, 49(12):1726-1733

Zhu JW, Xu YP, Zhang ZX, Cao WY, Cai XZ*. Transcript profiling for Avr4/Cf-4- and Avr9/Cf-9-dependent defence gene expression. European Journal of Plant Pathology, 2008, 122(2): 307-314

Cai XZ*, Zhou X, Xu YP, Joosten MHAJ, de Wit PJGM. Cladosporium fulvum CfHNNI1 induces hypersensitive necrosis, defence gene expression and disease resistance in both host and nonhost plants. Plant Molecular Biology, 2007, 64(1-2):89-101

Cai XZ, Wang CC, Xu YP, Xu QF, Zheng Z, and Zhou XP*. Efficient gene silencing induction in tomato by a viral satellite DNA vector. Virus Research. 2007, 125(2):169-175

Hong W, Xu YP, Zheng Z, Cao JS, Cai XZ*. Comparative transcript profiling by cDNA-AFLP reveals similar patterns of Avr4/Cf-4- and Avr9/Cf-9-dependent defence gene expression. Molecular Plant Pathology, 2007, 8(4):515-527

Xu YP, Cai XZ, and Zhou XP. Tomato leaf curl Guangxi virus is a distinct monopartite begomovirus species. European Journal of Plant Pathology, 2007, 118(3): 287-294.

Cai XZ*, Xu QF, Wang CC, and Zheng Z. Development of a virus-induced gene-silencing system for functional analysis of the RPS2-dependent resistance signalling pathways in Arabidopsis. Plant Molecular Biology, 2006, 62(1-2):223-232

Zhang HZ, and Cai XZ*. First record of Colletotrichum sp. in adlay in China. Journal of Plant Pathology, 2006, 88(2): 229-229.

Wang C, Cai X*, Wang X, and Zheng Z. Optimisation of tobacco rattle virus-induced gene silencing in Arabidopsis. Functional Plant Biology, 2006, 33(4):347-355

Wang C, Cai X*, Zheng Z. High humidity represses Cf-4/Avr4-and Cf-9/Avr9-dependent hypersensitive cell death and defense gene expression. Planta, 2005, 2226: 947-956.

Cai X*. Identification of amino acids of Cladosporium fulvum CfHNNI1 required for function of necrosis induction in plants. Acta Botanica Sinica. 2004, 46(6), 738-743.

De Jong CF, Takken FLW,Cai XZ,De Wit PJGM and Joosten MHAJ. Attenuation of Cf-mediated defense responses at elevated temperatures correlates with a decrease in elicitor-binding sites. Molecular Plant-Microbe Interactions, 2002, 15(10): 1040-1049.

Cai XZ, Xu YP. Avr/Cf interaction induces expression of Ptis, genes encoding Pto-interactors . Acta Botanica Sinica200244(5): 628-630

Cai X, Takken FLW, Joosten MHAJ, and De Wit PJGM. Specific recognition of AVR4 and AVR9 results in distinct patterns of hypersensitive cell death in tomato, but similar patterns of defence-related gene expression. Molecular Plant Pathology, 20012(2): 77-86. 2001-3

Joosten MHAJ, Cai X, Van der Hoorn R, De Jong CF, De Kock M, Lauge R, Luderer R, Roth R, Takken F, Vossen P, Weide R, Westerink N, and De Wit PJGM. Fuangal (a)virulence and host resistance in the Cladosporium fulvum-tomato interaction. In: Biology of Plant-Microbe Interactions Vol.2 Pierre de Wit, Ton Bisseling and Willem Stiekema (eds.) 2000, 29-34. IS-MPMI: St. Paul, Minnesota, USA (ISTP) 2000 

  




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