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时敏   副教授

 

杭州市西湖区余杭塘路866号

浙江大学紫金港校区农生环组团C座

邮编:310058

电话:0571-88982427

E-mail:shimin0623@zju.edu.cn

时    敏

• 简历

时敏,博士,副教授。2005年毕业于浙江大学获农学博士学位,2008年博士学位论文获全国百篇优秀博士学位论文提名奖。从事昆虫生物化学与分子生物学、进化生物学、生物资源发掘和利用、农作物害虫控制、及生物安全等领域的基础研究。

• 研究领域

  1. 寄生性天敌菜蛾盘绒茧蜂与寄主小菜蛾相互作用的生理与分子生物学基础;

  2. 寄生蜂多DNA病毒、畸形细胞的功能基因组学研究;

  3. 茧蜂科昆虫的系统发育与进化生物学

目前主持承担的主要科研项目包括:

1.国家自然科学基金面上项目,31672079,寄生蜂畸形细胞分泌型酶和酶抑制剂对寄主免疫的调控作用,2017/01-2020/12,55万(直接经费),在研,主持;

2.国家自然科学基金重点项目,31630060,寄生蜂PDVs对寄主小菜蛾脑神经肽的调控,2017/01-2021/12,282万(直接经费),在研,参加;

3.国家重点基础研究发展计划(973计划),2013CB127603,天敌昆虫控制害虫机制及可持续利用研究. 课题3:寄生性天敌昆虫与寄主互作的免疫机制,2013/01-2017/08,810万,在研,参加;

4.国家自然科学基金重点项目,31230068,膜翅目昆虫的系统发育与寄生习性进化,2013/01-2017/12,285万,在研,参加;

5.浙江省自然科学基金杰出青年项目,R3110049,寄生蜂多DNA病毒的基因表达及其对寄主小菜蛾脑激素肽的调控,2011/01-2013/12,30万,已结题,主持;

6.国家自然科学基金面上项目,30971907,两类多DNA病毒对寄主免疫细胞差异作用的机理研究,2010/01-2012/12,32万,已结题,主持;

7.国家自然科学基金面上项目,30871675,寄生蜂携带因子PDVs调控寄主小菜蛾的分子机理,2009/01-2011/12,33万,已结题,参加;

8.国家自然科学基金面上青年项目,30700063,中国茧蜂亚科分类及系统发育研究,2008/01-2010/12,15万元,已结题,主持;

9.国家重点基础研究发展计划(973计划):农业转基因生物安全风险评价与控制基础研究.课题2:转基因植物对动植物多样性影响的生态学规律(编号: 2007CB109202),2007-2011,参加;

10.7. 国家重点基础研究发展计划(973计划),2006CB102005,重大农业害虫猖獗危害的机制及可持续控制的基础研究. 课题5:天敌与害虫的互作及控害机制,2006/09-2010/09,421万,已结题,参加;

11.科技基础性工作专项:海南岛及西沙群岛生物资源调查:子课题:海南岛及西沙群岛昆虫资源调查(编号:2006FY110500-3),2006-2010,参加;

12.国家科技基础条件平台建设专项:经济昆虫种质资源标准化整理、整合及共享试点(编号:2005DKA21105),2006-2008,参加;

13.  中国博士后科学基金一等资助项目:菜蛾盘绒茧蜂PDV与寄主血细胞的作用机理(编号:20060400322),主持.

 

• 发表论著

  1. Shi M, Zhao S, Wang ZH, Stanley D, Chen XX. 2016. Cotesia vestalis parasitization suppresses expression of a Plutella xylostella thioredoxin. Insect molecular biology, 25(6): 679-688.

  2. Gao F, Gu QJ, Pan J, Wang ZH, Yin CL, Li F, Song QS, Strand MR, Chen XX, Shi M(通讯). 2016. Cotesia vestalis teratocytes express a diversity of genes and exhibit novel immune functions in parasitism. Scientific Reports, 6: e26967.

  3. Shi M, Dong S, Li MT, Yang YY, Stanley D, Chen XX. 2015. The endoparasitoid, Cotesia vestalis, Regulates host physiology by reprogramming the neuropeptide transcriptional network. Scientific Reports, 5: 8173.

  4. Shi M, Chen XY, Zhu N, Chen XX. 2014. Molecular identification of wo prophenoloxidase-activating proteases from the hemocytes of Plutella xylostella (Lepidoptera: Plutellidae) and their transcript abundance changes in response to microbial challenges. Journal of Insect Science, 14: 179.

  5. Shi M, Zhu N, Yin Y, Chen XX. 2013. Four serine protease cDNAs from the midgut of Plutella xylostella and their proteinase activity are influenced by the endoparasitoid, Cotesia vestalis. Archives of Insect Biochemistry and Physiology, 83(2): 101-114.

  6. Shi M, Wang YN, Zhu N, Chen XX. 2013. Four heat shock protein genes of the endoparasitoid wasp, Cotesia vestalis, and their transcriptional profiles in relation to developmental stages and temperature. PLos One, 8(3): e59721.

  7. Shi M, Huang F, Chen YF, Meng XF, Chen XX. 2009. Characterizat ion of midgut trypsinogen-like cdna and enzymatic activity in Plutella xylostella parasitized by Cotesia vestalis or Diadegma semiclausum. Archives of Insect Biochemistry and Physiology, 70(1): 3-17.

  8. Shi M, Chen YF, Yao Y, Huang F, Chen XX. 2008. Characterization of a protein tyrosine phosphatase gene CvBV202 from Cotesia vestalis polydnavirus (CvBV), Virus Genes, 36(3): 595-601.

  9. Shi M, Chen YF, Yao Y, Huang F, Liu PC, Zhou XP, Chen XX. 2008. Characterization of a novel gene encoding ankyrin repeat domain from Cotesia vestalis polydnavirus (CvBV), Virology, 374: 374-382.

  10. Shi M, Chen XX. 2005. Molecular phylogeny of the Aphidiinae (Hymenoptera: Braconidae) based on DNA sequences of 16S rRNA, 18S rDNA and ATPase 6 genes. European Journal of Entomology, 102: 133-138

  11. 1Shi M, Chen XX, van Achterberg C. 2005. Phylogenetic relationships among the Braconidae (Hymenoptera: Ichneumonoidea) inferred from partial 16S rDNA, 28S rDNA D2, 18S rDNA gene sequences and morphological characters. Molecular Phylogenetics and Evolution, 37(1): 104-116.

  12. Shi M, Chen XX, He JH. 2004. The genus Cedria Wilkinson of China (Hymenoptera: Braconidae). Proceedings of the Russian Entomological Society, St. Petersburg, 75 (1): 153–155.

  13. Shi M, Chen XX. 2004. Molecular differentiation of the microgastrine species commonly found in paddy fields from Southeast Asia, with additional data on their phylogeny (Hymenoptera: Braconidae). Insect Science, 12:155-162.

  14. Pu DQ, Shi M, Wu Q, Gao MQ, Liu JF, Ren SP, Yang F, Tang P, Ye GY, Shen ZC, He JH, Yang D, Bu WJ, Zhang CT, Song QS, Xu D, Strand MR, Chen XX. 2014. Flower-visiting insects and their potential impact on transgene flow in rice. Journal of Applied Ecology, 51(5): 1357-1365.

  15. Wang ZZ, Shi M, Ye XQ, Chen MY, Chen XX. 2013. Identification, characterization and expression of a defensin-like antifungal peptide from the whitefly Bemisia tabaci (Gennadius) (Hemiptera: Aleyrodidae). Insect Molecular Biology, 22(3): 297-305.

  16. Xu P, Shi M, Lai R, Chen XX. 2012. Differences in numbers of termicins expressed in two termite species affected by fungal contamination of their environments. Genetics and Molecular Research, 11(3): 2247-2257.

  17. Huang F, Shi M, Chen XX, Ye GY, He JH. 2009. External Morphology and development of immature stages of Diadegma semiclausum (Hymenoptera: Ichneumonidae), an important endoparasitoid of Plutella xylostella (Lepidoptera: Plutellidae). Annals of the Entomological Society of America, 102(3): 532-538.

  18. Huang F, Shi M, Yang YY, Li JY, Chen XX. 2009. Changes in hemocytes of Plutella xylostella after parasitism by Diadegma semiclausum. Archives of Insect Biochemistry and Physiology, 70(3): 177-187.

  19. Xu P, Shi M, Chen XX. 2009. Antimicrobial peptide evolution in the asiatic honey bee Apis cerana. PLos One, 4(1): e4239.

  20. Xu P, Shi M, Chen XX. 2009. Positive selection on Termicins in one termite species, Macrotermes barneyi (Isoptera: Termitidae). Sociobiology, 53(3): 739-753.

  21. Wei SJ, Shi M, He JH, Sharkey M, Chen XX. 2009. The complete mitochondrial genome of Diadegma semiclausum (Hymenoptera: Ichneumonidae) indicates extensive independent evolutionary. Genome, 52(4): 308-319.(SCI)

  22. Chen YF, Shi M, Liu PC, Huang F, Chen XX. 2008. Characterization of an IκB-like Gene in Cotesia vestalis Polydnavirus. Archives of Insect Biochemistry and Physiology, 68: 71-78.

  23. Huang F, Shi M, Chen YF, Cao TT, Chen XX. 2008. Oogenesis of Diadegma semiclausum (Hymenoptera: Ichneumonidae) and its associated polydnavirus. Microscopy Research and Technique, 71 (9): 676-683.

  24.  Meng XF, Shi M, Chen XX. 2008. Population genetic structure of Chilo suppressalis (Walker) (Lepidoptera: Crambidae): strong subdivision in China inferred from microsatellite markers and mtDNA gene sequences. Molecular Ecology, 17(12): 2880-2896.

  25. Zhang HY, Shi M, He JH, Chen XX. 2008. New species and records of the subgenus Microchelonus Szepligeti (Braconidae : Cheloninae) from China. Biologia, 63(1): 107-112.

  26. Chen YF, Shi M, Huang F, Chen XX. 2007. Characterization of two genes of Cotesia vestalis polydnavirus and their expression patterns in the host Plutella xylostella. Journal of General Viorolgy, 88: 3317-3322.

  27. 时敏, 陈学新. 2015. 我国寄生蜂调控寄主生理的研究进展,中国生物防治学报, 2015,31(5):620 ~ 637。

  28. 时敏, 朱兰兰, 陈学新. 2008, 基于28S rDNA D2基因片段与形态特征的优茧蜂亚科Euphorinae (膜翅目:茧蜂科) 系统发育研究, 昆虫分类学报,30(2): 113-130.

  29. 时敏, 张红英, 陈学新. 2008. 中国甲腹茧蜂属Chelonus Panzer长腹甲腹茧蜂种团elongatus-group三新记录种记述(膜翅目:茧蜂科:甲腹茧蜂亚科)。昆虫分类学报,30(3): 199-203.

  30. 时敏, 陈学新, 马云,何俊华. 2006. 基于28S rDNA D2基因片段与形态特征的矛茧蜂亚科Doryctinae(膜翅目:茧蜂科)系统发育研究. 昆虫学报, 50(2): 153-164.

  31. 陈晓宇, 时敏, 陈学新. 2015. 昆虫酚氧化酶原激活酶研究. 应用昆虫学报, 02: 281-288.

  32. 叶熹骞, 时敏, 陈学新. 2014. 寄生蜂携带的多DNA病毒的起源及其特性. 中国科学:生命科学, 04: 342-350.

  33. 黄芳, 时敏, 陈学新, 章金明. 2011. 半闭弯尾姬蜂寄生对寄主小菜蛾幼虫体液免疫的影响. 环境昆虫学报, 02: 154-158.

  34. 黄芳, 时敏, 陈学新, 章金明. 2011. 半闭弯尾姬蜂寄生及其毒液对小菜蛾幼虫血细胞吞噬作用的影响. Acta Entomologica Sinica, 09: 989-996.

  35. 郦卫弟, 时敏, 陈学新. 2007, 颈双缘姬蜂寄生引起小菜蛾蛹脂肪体形态和超微结构的变化.昆虫学报, 50(7): 662-666.