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李鲜

日期:2017-03-30

李鲜 

博士,教授,博士生导师。入选教育部教育部新世纪人才支持计划浙江省新世纪151人才工程(第二层次),浙江大学求是青年学者。浙江大学食品制造与贮藏物流研究中心副主任,浙江省“园艺产品品质调控技术研创与应用”国际科技合作基地主任。

      Email: xianli@zju.edu.cn

研究方向:

    1. 果实次生代谢物质与人类健康
    2. 果实采后品质变化的生物学机制
 

学习经历:

2012.12 - 今:浙江大学园艺系教授

2011.03 - 今:浙江大学求是青年学者

2010.04 - 2010.12: 法国国家工程院-国家农业科学院INP/INRA

2008.10 - 2009.08法国国家工程院-国家农业科学院INP/INRA

2005.12 - 2012.12浙江大学园艺系副教授

2004.12 - 2005.12浙江大学园艺系讲师 

科研项目: 

先后主持国家自然科学基金项目青年基金和面上项目,国家科技支撑计划项目,公益性行业科研专项课题,浙江省自然科学基金杰出青年项目、浙江省科学技术厅国际科技合作重点项目等多项。

    

科技奖励:
      
        作为主要完成人,作为主要完成人获得教育部自然科学奖和科技进步奖等省部级一等奖等3项。

  

发表主要论文:

  

    先后在Critical Reviews in Plant SciencesPlant, Cell & EnvironmentPlant Biotechnology JournalJournal of Agricultural and Food ChemistryJournal of Functional FoodsFood ChemistryPlantaPLOS ONEJournal of Separation Science,International Journal of Molecular SciencesPlant Foods for Human NutritionJournal of Medicinal Food、《园艺学报》、《果树学报》、《中国药学杂志》、《中国中药杂志》、《中草药》等国内外学术刊物上发表论文50余篇,SCI论文40余篇,主要论文如下:

  

  

Liu YL, Zhang WN, Xu CJ, Li X*. Biological activities of extracts from loquat (Eriobotrya japonica Lindl.): A review. International Journal of Molecular Sciences, 2016, 17: 1983; doi:10.3390  

Yan SX, Zhang XN, Wen X, Lv Q, Xu CJ, Sun CD, Li X*. Purification of flavonoids from Chinese bayberry (Morella rubra Sieb. et Zucc.) fruit extracts and α-glucosidase inhibitory activities of different fractionations. Molecules, 2016, 21: 1148

Zhang XN, Lv Q, Jia S, Chen YH, Sun CD, Li X*, Chen KS. Effects of flavonoids-rich Chinese bayberry (Morella rubra Sieb. et Zucc.) fruits extract on regulating glucose and lipids metabolism in diabetic KK-Ay mice. Food & Function, 2016, 7:3130-3140

Jia S, Gao ZW, Yan SX, Chen YH, Sun CD, Li X*, Chen KS. Anti-obesity and hypoglycemic effects of Poncirus trifoliata L. extracts in high-fat diet C57BL/6 mice. Molecules, 2016, 21: 453

Zeng JK#, Li X#, Zhang J, Ge H, Yin XR*, Chen KS. Regulation of loquat fruit low temperature response and lignification involves interaction of heat shock factors and genes associated with lignin biosynthesis. Plant, Cell & Environment, 2016, 39:1780-1789

Zeng JK#, Li X#, Xu Q, Chen JY, Yin XR*, Ian F, Chen KS. EjAP2-1, an AP2/ERF gene, is a novel regulator of fruit lignification induced by chilling injury, via interaction with EjMYB transcription factors. Plant Biotechnology Journal, 2015, 13(9): 1325-1334

Zhang XN, Huang HZ, Zhao XY, Lv Q, Sun CD, Li X*, Chen KS. Effects of flavonoids-rich Chinese bayberry (Myrica rubra Sieb. et Zucc.) pulp extracts on glucose consumption in human HepG2 cells. Journal of Functional Foods, 2015, 14: 144-153

Zhang XN, Huang HZ, Zhang QL, Fan FJ, Xu CJ, Sun CD, Li X*, Chen KS. Phytochemical characterization of Chinese bayberry (Myrica rubra Sieb. et Zucc.) of 17 cultivars and their antioxidant properties. International Journal of Molecular Sciences, 2015, 16: 12467-12481

Zhao XY, Zhang WN, Yin XR, Su MS, Sun CD, Li X*, Chen KS. Phenolic composition and antioxidant properties of different peach [Prunus persica (L.) Batsch] cultivars in China. International Journal of Molecular Sciences, 2015, 16: 5762-5778

Lv Q, Luo FL, Liu Y, Hu GB, Sun CD, Li X*, Chen KS. Identification of proanthocyanidins from litchi (Litchi chinensis Sonn.) pulp by LC-ESI-Q-TOF-MS and their antioxidant activity. PLoS ONE, 2015, 10(3): e0120480

Jia S, Hu Y, Zhang WN, Zhao XY, Chen YH, Sun CD, Li X*, Chen KS. Hypoglycemic and hypolipidemic effects of neohesperidin on diabetic KK-Ay mice. Food & Function, 2015, 6: 878-886

Zhang WN, Zhao XY, Sun CD, Li X*, Chen KS. Phenolic composition from different loquat (Eriobotrya japonica Lindl.) cultivars grown in China and their antioxidant properties. Molecules, 2015, 20: 542-555

Zhang JK, Wu YP, Zhao XY, Luo FL, Li X*, Zhu H, Sun CD, Chen KS. Chemopreventive effect of flavonoids from Ougan (Citrus reticulata cv. Suavissima) fruit against cancer cell proliferation and migration. Journal of Functional Foods, 2014, 10: 511-519

Luo FL, Fu YY, Xiang Y, Hu GB, Huang XM, Huang GD, Sun CD, Li X*, Chen KS. Identification and quantification of gallotannins in mango (Mangifera indica L.) kernel and peel and their antiproliferative activities. Journal of Functional Foods, 2014, 8: 282-291

Lv Q, Si MM, Yan YY, Luo FL, Hu GB, Wu HS, Sun CD, Li X*, Chen KS. Effects of phenolic-rich litchi (Litchi chinensis Sonn.) pulp extracts on glucose consumption in human HepG2 cells. Journal of Functional Foods, 2014, 7: 621-629

Sun CD, Huang HZ, Xu CJ, Li X*, Chen KS. Biological activities of extracts from Chinese bayberry (Myrica rubra Sieb. et Zucc.): A Review. Plant Foods for Human Nutrition, 2013, 68:97-106

Luo FL, Lv Q, Zhao YQ, Hu GB, Huang GD, Zhang JK, Sun CD, Li X*. Chen KS. Characterization, purification of mangiferin from Chinese mango (Mangifera indica L.) cultivars and its protective effect in human umbilical vein endothelial cells under H2O2-induced stress. International Journal of Molecular Sciences, 2012, 13(9): 11260-11274

Zhang JK, Sun CD, Yan YY, Chen QJ, Luo FL, Zhu XY, Li X*, Chen KS. Purification of naringin and neohesperidin from Huyou (Citrus changshanensis) fruit and their effects on glucose consumption in human HepG2 cells. Food Chemistry, 2012, 135(3): 1471-1478

Sun CD, Zhang B, Zhang JK, Xu CJ, Wu YL, Li X*, Chen KS. Cyanidin-3-glucoside-rich extract from Chinese bayberry fruit protects pancreatic β cells and ameliorates hyperglycemia in streptozotocin-induced diabetic mice. Journal of Medicinal Food. 2012, 15 (3): 288-298

Zhang JK, Zhu XY, Luo FL, Sun CD, Huang JZ, Li X*, Chen KS. Separation and purification of neohesperidin from the albedo of Citrus reticulata cv. Suavissima by combination of macroporous resin and high-speed counter-current chromatography. Journal of Separation Science, 2012, 35(1):128-136

Sun CD, Zheng YX, Chen QJ, Tang XL, Jiang M, Zhang JK, Li X*, Chen KS. Purification and anti-tumor activity of cyanidin-3-O-glucoside from Chinese bayberry fruit. Food Chemistry, 2012, 131(4): 1287-1294

Zhang SY#, Li X#, Feng C, Zhu CQ, Grierson D, Xu CJ, Chen KS. Development and characterization of 109 polymorphic EST-SSRs derived from the Chinese bayberry (Myrica rubra, Myricaceae) transcriptome. American Journal of Botany, 2012, 99(12):e501-507

Zhou CH, Sun CD, Chen KS, Li X*. Flavonoids, phenolics, and antioxidant capacity in the flower of Eriobotrya japonica Lindl. International Journal of Molecular Sciences,2011, 12(5): 2935-2945

Zhou CH, Li X*, Zhang WS, Sun CD, Chen KS. Oleanolic and ursolic acid in the fruit of Eriobotrya japonica Lindl. Journal of Medicinal Plants Research, 2011, 5(9): 1735-1740

Jiang TM, Wang P, Yin XR, Zhang B, Xu CJ, Li X*, Chen KS. Ethylene biosynthesis and expression of related genes in loquat fruit at different developmental and ripening stages. Scientia Horticulturae, 2011, 130(2): 452-458

Li X, Xu CJ, Korban SS, Chen KS. Regulatory mechanisms of textural changes in ripening fruits. Critical Reviews in Plant Sciences, 2010, 29(4): 222-243

Shan LL#, Li X#, Wang P, Cai C, Zhang B, Sun CD, Zhang WS, Xu CJ, Ferguson IB, Chen KS. Characterization of cDNAs associated with lignification and their expression profiles in loquat fruit with different lignin accumulation. Planta, 2008, 227: 1243-1254

Li X, Wen ZM, Bohnert HJ, Schuler MA, Kushad MM. Myrosinase in horseradish (Armoracia rusticana) root: Isolation of a full-length cDNA and its heterologous expression in Spodoptera frugiperda insect cells. Plant Science, 2007, 172(6): 1095-1102

Zhou CH, Chen KS, Sun CD, Chen QJ, Zhang WS, Li X*. Determination of oleanolic acid, ursolic acid, and amygdalin in the flower of Eriobotrya japonica Lindl. by HPLC. Biomedical Chromatography, 2007, 21(7): 755-761

Li X, Kushad MM, Purification and characterization of myrosinase enzyme from horseradish (Armoracia rusticana) root. Plant Physiology and Biochemistry, 2005, 43(6): 503-511

Li X, Kushad MM, Correlation of glucosinolate content to myrosinase activity in horseradish (Armoracia rusticana). Journal of Agricultural and Food Chemistry, 2004, 52(23): 6950-6955

 

授权专利:

  

一种从芒果中富集具有较高抗氧化活性的没食子单宁的方法国家发明专利ZL201210053385.9

一种从胡柚白皮层分离纯化柚皮苷和新橙皮苷的方法,国家发明专利ZL2012100145574.1

一种从荔枝果肉中提取原花青素的方法国家发明专利号ZL201410501667.X

新橙皮苷在制备防治糖尿病药物中的应用国家发明专利ZL201210199606

芒果粗提物在制备治疗心血管疾病的药物和食品用途国家发明专利号ZL201310230247.8

一种芒果提取物在制备抗肿瘤药物中的应用国家发明专利号201310230250.

一种从柚类果实囊衣中分离纯化柠檬苦素类化合物的方法,国家发明专利ZL201310384041.0

一种生产富含花青苷烟草的方法国家发明专利ZL201210338263.4

一种枳提取物的降脂用途国家发明专利号ZL201510216162.3

一种椪柑果实贮藏方法,国家发明专利ZL201210432611.4

一种维持杨梅果实采后物流微环境低温的方法,国家发明专利ZL201310565218.7

一种水蜜桃果实贮藏方法,国家发明专利ZL200810162751.8





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